|
在接受顺铂、异环磷酰胺、或阿霉素治疗的儿童青少年血浆肉碱水平与疲劳 Carnitine Plasma Levels and Fatigue in ChildrenAdolescents ReceiviSummary: Fatigue is the most frequent symptom experienced by children/adolescents with cancer. One mechanism contributing to cancer-related fatigue involves abnormalities in adenosine tri- phosphate synthesis caused by carnitine deficiency. The purpose of this study was to examine fatigue and carnitine in children,i adolescents before and after ifosfamide, cisplatin, or doxorubicin chemotherapy. Sixty-seven patients from 2 children's cancer centers participated. Fatigue and carnitine measures were obtained before chemotherapy and a week later. Newly diagnosed children,iado- lescents had significantly higher free (P一0.018) and total carnitine levels (P一0.017) compared with those who received prior chemo-therapy. There was a significant increase in free and total carnitine levels after treatment for patients receiving doxorubicin than patients receiving cisplatin or ifosfamide. Increased fatigue and decreased carnitine were significantly correlated a week after chemotherapy in children,iadolescents who had received prior chemotherapy. Increased carnitine in newly diagnosed patients is likely associated with rapid tissue release into the bloodstream,replacing carnitine lost by chemotherapy metabolism. Decreased carnitine and increased fatigue occurred after 1 to 2 courses of chemotherapy. This study provides support for a relationship between carnitine and fatigue in children/adolescents with cancer. 详情请点击下载PDF文件。 |
一起探索
最有价值的医学知识